MolNFT v1 · #190348 · protein
Crystal structure of mutt-8-oxo-dgtp complex: reaction for 1.5 hr in 20 mm MN2+
7WW9 · 7,8-dihydro-8-oxoguanine-triphosphatase: “Crystal structure of mutt-8-oxo-dgtp complex: reaction for 1.5 hr in 20 mm MN2+”. X-ray diffraction, 5 ligands (8DG, 8OG, MN), 1 pocket (best druggability 0.62). MolNFT v1 #190348 on…
- PDB
- 7WW9
- Type
- protein
- Length
- 129 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 7,8-dihydro-8-oxoguanine-triphosphatase
- EC
- 3.6.1.55, 3.6.1.-
- UniProt
- A0A037YRW7
- Ligands
- 8DG, 8OG, MN, NA, SO4
- Pockets
- 1 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 7,8-dihydro-8-oxoguanine-triphosphatase (EC 3.6.1.55, 3.6.1.-) | protein | 129 | 21% helix, 41% strand | A0A037YRW7 |
Ligands and binding sites
- 8DG · 8-oxo-2'-deoxyguanosine-5'-triphosphate · ligand · chains A
- 8OG · 8-oxo-2'-deoxy-guanosine-5'-monophosphate · ligand · chains A
- MN · Manganese (II) ion · metal · 3 copies · chains A
- NA · Sodium ion · metal · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 173 | 0.62 | 0.84 | 29 | 8DG, 8OG, MN |
Compared structures
- 7WW9 · Crystal structure of MutT-8-oxo-dGTP complex: Reaction for 1.5 hr in 20 mM Mn2+ · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0A037YRW7
- Elsewhere: RCSB PDB 7WW9 · PDBe 7WW9 · UniProt A0A037YRW7
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