MolNFT v1 · #19031 · protein

Brain tumor nhl domain

1Q7F · Brain tumor CG10719-pa: “Brain tumor nhl domain”. X-ray diffraction, 4 pockets (best druggability 0.72). MolNFT v1 #19031 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Q7F
Type: protein
Length: 561 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Brain tumor CG10719-pa
UniProt: Q8MQJ9
Pockets: 4 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 51% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Brain tumor CG10719-pa	protein	279	3% helix, 51% strand	Q8MQJ9
B	Brain tumor CG10719-pa	protein	282	2% helix, 50% strand	Q8MQJ9

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	432	0.72	0.83	53	empty
2	897	0.70	0.76	86	empty
3	301	0.70	0.84	38	empty
4	109	0.42	0.77	16	empty

Interfaces

1 interface between chains.

A–B · 890 Å² buried · 17 hydrogen bonds · protein-protein

Compared structures

1Q7F · Brain Tumor NHL domain · the same entry in another collection · chain A against A, TM-score 1.00
Q8MQJ9 · AlphaFold monomer V2.0 prediction for brain tumor protein (Q8MQJ9) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8MQJ9
Elsewhere: RCSB PDB 1Q7F · PDBe 1Q7F · UniProt Q8MQJ9

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