MolNFT v1 · #190285 · protein
Structure of human IGF1/IGFBP3/ALS ternary complex
7WRQ · Insulin-like growth factor-binding protein complex acid…: “Structure of human IGF1/IGFBP3/ALS ternary complex”. Electron microscopy, 2 ligands (NAG, BMA), 13 pockets (best druggability 0.79). MolNFT v1 #190285 on GenesisL1: 3D…
- PDB
- 7WRQ
- Type
- protein
- Length
- 798 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin-like growth factor-binding protein complex acid labile subunit; Insulin-like…
- UniProt
- P35858, P17936, P05019
- Ligands
- NAG, BMA
- Pockets
- 13 · best druggability 0.79
Structure
electron microscopy · 3 distinct chains · 7% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Insulin-like growth factor-binding protein complex acid labile subunit | protein | 566 | 2% helix, 9% strand | P35858 |
| B | Insulin-like growth factor-binding protein 3 | protein | 167 | 12% helix, 16% strand | P17936 |
| C | Isoform 3 of insulin-like growth factor I | protein | 65 | 34% helix, 3% strand | P05019 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A, B
- BMA · beta-D-mannopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1166 | 0.79 | 0.81 | 92 | empty |
| 2 | 749 | 0.70 | 0.77 | 71 | empty |
| 3 | 97 | 0.66 | 0.90 | 27 | empty |
| 4 | 237 | 0.55 | 0.77 | 33 | empty |
| 5 | 69 | 0.52 | 0.85 | 18 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1575 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 1429 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 623 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 18 disulfide, 5 glycan (disulfide, N-glycosylation).
Compared structures
- 7WRQ · Structure of Human IGF1/IGFBP3/ALS Ternary Complex · the same entry in another collection · chain A against A, TM-score 1.00
- P35858 · AlphaFold monomer V2.0 prediction for insulin-like growth factor- binding protein complex… · a predicted model of the same protein · chain A against A, TM-score 0.89
- P05019 · AlphaFold monomer V2.0 prediction for insulin-like growth factor I (P05019) · a predicted model of the same protein · chain C against A, TM-score 0.74
- P17936 · AlphaFold monomer V2.0 prediction for insulin-like growth factor- binding protein 3… · a predicted model of the same protein · chain B against A, TM-score 0.70
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35858
- Every structure of UniProt P17936
- Every structure of UniProt P05019
- Elsewhere: RCSB PDB 7WRQ · PDBe 7WRQ · UniProt P35858 · UniProt P17936 · UniProt P05019
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