MolNFT v1 · #190169 · protein + RNA
Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and M6A-containing ssrna
7WKV: “Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and M6A-containing ssrna”. X-ray diffraction, 2 ligands (AKG, MN). MolNFT v1 #190169 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7WKV
- Type
- protein + RNA
- Length
- 669 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q6P6C2
- Ligands
- AKG, MN
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C, E | — | protein | 219 | — | Q6P6C2 |
| B, D, F | — | rna | 4 | — | — |
Ligands and binding sites
- AKG · 2-oxoglutaric acid · ligand · 3 copies · chains A, B, C, D, E, F
- MN · Manganese (II) ion · metal · 3 copies · chains A, B, C, E
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7WKV · Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing… · the same entry in another collection · chain F against F, TM-score 1.00
- Q6P6C2 · AlphaFold monomer V2.0 prediction for RNA demethylase ALKBH5 (Q6P6C2) · a predicted model of the same protein · chain E against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6P6C2
- Elsewhere: RCSB PDB 7WKV · PDBe 7WKV · UniProt Q6P6C2
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