UniProt Q6P6C2
RNA demethylase ALKBH5 (Q6P6C2)
RNA demethylase ALKBH5 (UniProt Q6P6C2), EC 1.14.11.53: 22 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 4 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q6P6C2
- Protein
- RNA demethylase ALKBH5
- EC
- 1.14.11.53
- Experimental structures
- 22
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 4 · 1 record with a druggable one
Structures
23 records of Q6P6C2 in the MolNFT archive: 22 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4NJ4 | Crystal Structure of Human ALKBH5 | x-ray diffraction | A, B | — | — |
| 4NJ4 | Crystal structure of human ALKBH5 | x-ray diffraction | A, B | — | — |
| 4NRM | Crystal structure of human ALKBH5 in complex with citrate and acetate | x-ray diffraction | A | — | — |
| 4NRM | Crystal structure of human ALKBH5 in complex with citrate and acetate | x-ray diffraction | A | — | — |
| 4NRO | Crystal structure of human ALKBH5 in complex with alpha-ketoglutarate | x-ray diffraction | A | — | — |
| 4NRO | Crystal structure of human ALKBH5 in complex with alpha-ketoglutarate | x-ray diffraction | A | — | — |
| 4NRP | Crystal structure of human ALKBH5 in complex with N-oxalylglycine | x-ray diffraction | A | — | — |
| 4NRP | Crystal structure of human ALKBH5 in complex with N-oxalylglycine | x-ray diffraction | A | — | — |
| 4NRQ | Crystal structure of human ALKBH5 in complex with pyridine-2,4-dicarboxylate | x-ray diffraction | A | — | — |
| 4NRQ | Crystal structure of human ALKBH5 in complex with pyridine-2,4- dicarboxylate | x-ray diffraction | A | — | — |
| 4O61 | Structure of human ALKBH5 crystallized in the presence of citrate | x-ray diffraction | A, B | — | — |
| 4O61 | Structure of human ALKBH5 crystallized in the presence of citrate | x-ray diffraction | A, B | — | — |
| 4O7X | Crystal structure of human ALKBH5 in complex with Mn2+ | x-ray diffraction | A | — | — |
| 4O7X | Crystal structure of human ALKBH5 in complex with MN2+ | x-ray diffraction | A | — | — |
| 4OCT | Crystal structure of human ALKBH5 crystallized in the presence of Mn^{2+} and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 4OCT | Crystal structure of human ALKBH5 crystallized in the presence of MN^{2+} and 2-oxoglutarate | x-ray diffraction | A, B | — | — |
| 7V4G | Crystal structure of human ALKBH5 in complex with m6A-containing ssRNA | x-ray diffraction | A, B, C | MN, SO4 | — |
| 7V4G | Crystal structure of human ALKBH5 in complex with M6A-containing ssrna | x-ray diffraction | A, B, C | MN, SO4 | — |
| 7WKV | Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing ssRNA | x-ray diffraction | A, C, E | MN, AKG | 4 (best 0.78) |
| 7WKV | Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and M6A-containing ssrna | x-ray diffraction | A, C, E | MN, AKG | — |
| 7WL0 | Crystal structure of human ALKBH5 in complex with N-oxalylglycine (NOG) and m6A-containing ssRNA | x-ray diffraction | A, C, E, G, I | MN, OGA | — |
| 7WL0 | Crystal structure of human ALKBH5 in complex with N-oxalylglycine (nog) and M6A-containing ssrna | x-ray diffraction | A, C, E, G, I | MN, OGA | — |
| Q6P6C2 | AlphaFold monomer V2.0 prediction for RNA demethylase ALKBH5 (Q6P6C2) | predicted | A | — | — |
Ligands
Experiment against prediction
- 7V4G chain B against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.66 Å
- 7V4G chain B against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.66 Å
- 7WKV chain E against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.68 Å
- 7WKV chain E against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.68 Å
- 7V4G chain A against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.67 Å
- 7V4G chain A against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.67 Å
- 7WL0 chain A against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.68 Å
- 7WL0 chain A against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.68 Å
- 7WL0 chain E against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.70 Å
- 7WL0 chain E against the predicted model Q6P6C2: TM-score 0.99, RMSD 0.70 Å
Elsewhere
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