MolNFT v1 · #190131 · protein
Cryo-EM structure of LY2794193-bound MGLU3
7WIH · Metabotropic glutamate receptor 3: “Cryo-EM structure of LY2794193-bound MGLU3”. Electron microscopy, 2 ligands (CWY, NAG), 17 pockets (best druggability 0.83). MolNFT v1 #190131 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7WIH
- Type
- protein
- Length
- 1,482 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Metabotropic glutamate receptor 3
- UniProt
- Q14832
- Ligands
- CWY, NAG
- Pockets
- 17 · best druggability 0.83
Structure
electron microscopy · 1 distinct chain · 27% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Metabotropic glutamate receptor 3 | protein | 741 | 27% helix, 7% strand | Q14832 |
Ligands and binding sites
- CWY · (1S,2S,4S,5R,6S)-2-amino-4-[(3-methoxybenzene-1-carbonyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid · ligand · 2 copies · chains A, B
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1136 | 0.83 | 0.84 | 130 | CWY |
| 2 | 282 | 0.76 | 0.88 | 50 | empty |
| 3 | 674 | 0.76 | 0.81 | 69 | empty |
| 4 | 285 | 0.74 | 0.87 | 52 | empty |
| 5 | 613 | 0.73 | 0.80 | 64 | empty |
Interfaces
1 interface between chains.
- A–B · 821 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14832
- Elsewhere: RCSB PDB 7WIH · PDBe 7WIH · UniProt Q14832
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