MolNFT v1 · #189868 · protein
Coxsackievirus B3 at PH7.4 (VP3-234E) incubation with coxsackievirus and adenovirus receptor for 20MIN
7W14 · Capsid protein VP1: “Coxsackievirus B3 at PH7.4 (VP3-234E) incubation with coxsackievirus and adenovirus receptor for 20MIN”. Electron microscopy, 13 pockets (best druggability 0.80). MolNFT v1 #189868 on GenesisL1: 3D structure…
- PDB
- 7W14
- Type
- protein
- Length
- 946 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Capsid protein VP1; Capsid protein VP2; Capsid protein VP3; Capsid protein VP4…
- UniProt
- P78310
- Pockets
- 13 · best druggability 0.80
Structure
electron microscopy · 5 distinct chains · 10% helix, 34% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Capsid protein VP1 | protein | 270 | 9% helix, 32% strand | — |
| B | Capsid protein VP2 | protein | 256 | 11% helix, 36% strand | — |
| C | Capsid protein VP3 | protein | 238 | 11% helix, 30% strand | — |
| D | Capsid protein VP4 | protein | 58 | 10% helix, 16% strand | — |
| E | Coxsackievirus and adenovirus receptor | protein | 124 | 7% helix, 47% strand | P78310 |
Pockets
13 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 748 | 0.80 | 0.84 | 75 | empty |
| 2 | 73 | 0.49 | 0.84 | 21 | empty |
| 3 | 113 | 0.47 | 0.79 | 19 | empty |
| 4 | 137 | 0.46 | 0.77 | 25 | empty |
| 5 | 162 | 0.46 | 0.76 | 29 | empty |
Interfaces
8 interfaces between chains.
- A–C · 4312 Ų buried · 65 hydrogen bonds · protein-protein
- A–B · 2191 Ų buried · 29 hydrogen bonds · protein-protein
- B–C · 1620 Ų buried · 17 hydrogen bonds · protein-protein
- A–D · 1165 Ų buried · 14 hydrogen bonds · protein-protein
- C–D · 903 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 7W14 · Coxsackievirus B3 at pH7.4 (VP3-234E) incubation with coxsackievirus and adenovirus… · the same entry in another collection · chain A against A, TM-score 1.00
- P78310 · AlphaFold monomer V2.0 prediction for coxsackievirus and adenovirus receptor (P78310) · a predicted model of the same protein · chain E against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P78310
- Elsewhere: RCSB PDB 7W14 · PDBe 7W14 · UniProt P78310
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