MolNFT v1 · #189847 · protein

DICER2-loqspd complex at apo status

7W0B · Dicer-2, isoform a: “DICER2-loqspd complex at apo status”. Electron microscopy, 20 pockets (best druggability 0.77). MolNFT v1 #189847 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7W0B
Type: protein
Length: 1,602 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Dicer-2, isoform a; Loquacious, isoform D
EC: 3.1.21.1, 3.1.26.-, 3.1.26.3, 3.6.1.3
UniProt: A1ZAW0, M9MRT5
Pockets: 20 · best druggability 0.77

Structure

electron microscopy · 2 distinct chains · 47% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Dicer-2, isoform a (EC 3.1.21.1, 3.1.26.-, 3.1.26.3, 3.6.1.3)	protein	1586	47% helix, 10% strand	A1ZAW0
B	Loquacious, isoform D	protein	16	0% helix, 13% strand	M9MRT5

Pockets

20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	779	0.77	0.81	89	empty
2	389	0.76	0.86	50	empty
3	557	0.75	0.82	67	empty
4	368	0.72	0.84	42	empty
5	89	0.71	0.94	22	empty

Interfaces

1 interface between chains.

A–B · 1041 Å² buried · 11 hydrogen bonds · protein-protein

Compared structures

7W0B · Dicer2-LoqsPD complex at apo status · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A1ZAW0
Every structure of UniProt M9MRT5
Elsewhere: RCSB PDB 7W0B · PDBe 7W0B · UniProt A1ZAW0 · UniProt M9MRT5

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