MolNFT v1 · #189663 · protein
Crystal structure of transportin-1 in complex with BAP1 py-nls (residues 706-724)
7VPW · BRCA1-associated protein 1 (BAP1): “Crystal structure of transportin-1 in complex with BAP1 py-nls (residues 706-724)”. X-ray diffraction, 5 pockets (best druggability 0.42). MolNFT v1 #189663 on GenesisL1: 3D structure, binding…
- PDB
- 7VPW
- Type
- protein
- Length
- 841 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- BRCA1-associated protein 1 (BAP1); Transportin-1
- UniProt
- B3KS40, Q92973
- Pockets
- 5 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 79% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | BRCA1-associated protein 1 (BAP1) | protein | 7 | 0% helix, 0% strand | B3KS40 |
| A | Transportin-1 | protein | 834 | 80% helix, 0% strand | Q92973 |
Pockets
5 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 145 | 0.42 | 0.75 | 20 | empty |
| 2 | 104 | 0.39 | 0.76 | 14 | empty |
| 3 | 102 | 0.36 | 0.74 | 17 | empty |
| 4 | 83 | 0.32 | 0.74 | 22 | empty |
| 5 | 61 | 0.29 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- B–A · 489 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 7VPW · Crystal structure of Transportin-1 in complex with BAP1 PY-NLS (residues 706-724) · the same entry in another collection · chain B against B, TM-score 1.00
- Q92973 · AlphaFold monomer V2.0 prediction for transportin-1 (Q92973) · a predicted model of the same protein · chain A against A, TM-score 0.86
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt B3KS40
- Every structure of UniProt Q92973
- Elsewhere: RCSB PDB 7VPW · PDBe 7VPW · UniProt B3KS40 · UniProt Q92973
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