MolNFT v1 · #189531 · protein

Human alkb homolog ALKBH6 in complex with tris and ni

7VJS · Alpha-ketoglutarate-dependent dioxygenase alkb homolog 6: “Human alkb homolog ALKBH6 in complex with tris and ni”. X-ray diffraction, 1 ligand (NI), 1 pocket (best druggability 0.61). MolNFT v1 #189531 on GenesisL1: 3D structure…

PDB: 7VJS
Type: protein
Length: 205 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alpha-ketoglutarate-dependent dioxygenase alkb homolog 6
EC: 1.14.11.-
UniProt: Q3KRA9
Ligands: NI
Pockets: 1 · best druggability 0.61

Structure

x-ray diffraction · 1 distinct chain · 20% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Alpha-ketoglutarate-dependent dioxygenase alkb homolog 6 (EC 1.14.11.-)	protein	205	20% helix, 33% strand	Q3KRA9

Ligands and binding sites

NI · Nickel (II) ion · metal · chains A
TRS · 2-amino-2-hydroxymethyl-propane-1,3-diol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	150	0.61	0.84	25	NI, TRS

Compared structures

7VJS · Human AlkB homolog ALKBH6 in complex with Tris and Ni · the same entry in another collection · chain A against A, TM-score 1.00
Q3KRA9 · AlphaFold monomer V2.0 prediction for alpha-ketoglutarate-dependent dioxygenase alkb… · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q3KRA9
Elsewhere: RCSB PDB 7VJS · PDBe 7VJS · UniProt Q3KRA9

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