MolNFT v1 · #18941 · protein

The structure of the polo box domain of human PLK1

1Q4O · SERINE/THREONINE-protein kinase plk: “The structure of the polo box domain of human PLK1”. X-ray diffraction, 6 pockets (best druggability 0.47). MolNFT v1 #18941 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1Q4O
Type: protein
Length: 415 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: SERINE/THREONINE-protein kinase plk
EC: 2.7.1.-
UniProt: P53350
Pockets: 6 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 32% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	SERINE/THREONINE-protein kinase plk (EC 2.7.1.-)	protein	207	34% helix, 32% strand	P53350
B	SERINE/THREONINE-protein kinase plk (EC 2.7.1.-)	protein	208	30% helix, 31% strand	P53350

Pockets

6 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	113	0.47	0.79	17	empty
2	89	0.44	0.79	15	empty
3	83	0.39	0.77	13	empty
4	52	0.32	0.77	12	empty
5	51	0.29	0.75	13	empty

Interfaces

1 interface between chains.

A–B · 343 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1Q4O · The structure of the polo box domain of human Plk1 · the same entry in another collection · chain A against A, TM-score 1.00
P53350 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase PLK1 (P53350) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P53350
Elsewhere: RCSB PDB 1Q4O · PDBe 1Q4O · UniProt P53350

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