MolNFT v1 · #189292 · protein
Crystal structure of mouse CRY2 in complex with SHP656 compound
7V8Z · Cryptochrome-2: “Crystal structure of mouse CRY2 in complex with SHP656 compound”. X-ray diffraction, 1 ligand (5YH), 2 pockets (best druggability 0.76). MolNFT v1 #189292 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7V8Z
- Type
- protein
- Length
- 490 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cryptochrome-2
- UniProt
- Q9R194
- Ligands
- 5YH
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 8% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cryptochrome-2 | protein | 490 | 51% helix, 8% strand | Q9R194 |
Ligands and binding sites
- 5YH · 1-[(2R)-3-[3,6-bis(fluoranyl)carbazol-9-yl]-2-oxidanyl-propyl]imidazolidin-2-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 666 | 0.76 | 0.81 | 50 | 5YH |
| 2 | 519 | 0.72 | 0.81 | 41 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9R194
- Elsewhere: RCSB PDB 7V8Z · PDBe 7V8Z · UniProt Q9R194
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