UniProt Q9R194
Cryptochrome-2 (Q9R194)
Cryptochrome-2 (UniProt Q9R194): 17 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 10 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9R194
- Protein
- Cryptochrome-2
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 10 · 2 records with a druggable one
Structures
18 records of Q9R194 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4I6E | A vertebrate cryptochrome | x-ray diffraction | A | — | — |
| 4I6E | A vertebrate cryptochrome | x-ray diffraction | A | — | — |
| 4I6G | a vertebrate cryptochrome with FAD | x-ray diffraction | A, B | — | — |
| 4I6G | A vertebrate cryptochrome with FAD | x-ray diffraction | A, B | — | — |
| 4I6J | A ubiquitin ligase-substrate complex | x-ray diffraction | A | — | — |
| 4I6J | A ubiquitin ligase-substrate complex | x-ray diffraction | A | — | — |
| 4MLP | Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase | x-ray diffraction | C, A, B, D | — | — |
| 4MLP | Mammalian cryptochrome in complex with a small molecule competitor of its ubiquitin ligase | x-ray diffraction | C, A, B, D | — | — |
| 4U8H | Crystal Structure of Mammalian Period-Cryptochrome Complex | x-ray diffraction | A, C | — | — |
| 4U8H | Crystal structure of mammalian period-cryptochrome complex | x-ray diffraction | A, C | — | — |
| 6KX8 | Crystal structure of mouse Cryptochrome 2 in complex with TH301 compound | x-ray diffraction | A, B | DYX | 7 (best 0.79) |
| 6KX8 | Crystal structure of mouse cryptochrome 2 in complex with TH301 compound | x-ray diffraction | A, B | DYX | — |
| 7D0N | Crystal structure of mouse CRY2 apo form | x-ray diffraction | A | — | — |
| 7EJ9 | Alternative crystal structure of mouse cryptochrome 2 in complex with TH301 compound | x-ray diffraction | A, B | DYX | — |
| 7V8Y | Crystal structure of mouse CRY2 in complex with SHP1703 compound | x-ray diffraction | A | 5YH | 3 (best 0.76) |
| 7V8Y | Crystal structure of mouse CRY2 in complex with SHP1703 compound | x-ray diffraction | A | 5YH | — |
| 7V8Z | Crystal structure of mouse CRY2 in complex with SHP656 compound | x-ray diffraction | A | 5YH | — |
| Q9R194 | AlphaFold monomer V2.0 prediction for cryptochrome-2 (Q9R194) | predicted | A | — | — |
Ligands
Experiment against prediction
- 6KX8 chain A against the predicted model Q9R194: TM-score 0.99, RMSD 0.72 Å
- 6KX8 chain A against the predicted model Q9R194: TM-score 0.99, RMSD 0.72 Å
- 6KX8 chain B against the predicted model Q9R194: TM-score 0.99, RMSD 0.77 Å
- 6KX8 chain B against the predicted model Q9R194: TM-score 0.99, RMSD 0.77 Å
- 7EJ9 chain B against the predicted model Q9R194: TM-score 0.99, RMSD 0.83 Å
- 4I6G chain B against the predicted model Q9R194: TM-score 0.99, RMSD 0.79 Å
- 4I6G chain B against the predicted model Q9R194: TM-score 0.99, RMSD 0.79 Å
- 4I6E chain A against the predicted model Q9R194: TM-score 0.99, RMSD 0.79 Å
- 4I6E chain A against the predicted model Q9R194: TM-score 0.99, RMSD 0.79 Å
- 7D0N chain A against the predicted model Q9R194: TM-score 0.99, RMSD 0.85 Å
Elsewhere
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