MolNFT v1 · #189197 · protein

Crystal structure of human bleomycin hydrolase C73A mutant

7V5S: “Crystal structure of human bleomycin hydrolase C73A mutant”. X-ray diffraction, 5 pockets (best druggability 0.57). MolNFT v1 #189197 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7V5S
Type: protein
Length: 454 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bleomycin hydrolase
EC: 3.4.22.40
UniProt: Q13867
Pockets: 5 · best druggability 0.57

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bleomycin hydrolase (EC 3.4.22.40)	protein	454	45% helix, 18% strand	Q13867

Ligands and binding sites

PG4 · Tetraethylene glycol · additive · chains A
PGE · Triethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	136	0.57	0.83	26	empty
2	84	0.37	0.76	22	empty
3	76	0.32	0.74	18	empty
4	50	0.31	0.76	15	empty
5	56	0.30	0.75	14	empty

Compared structures

7V5S · Crystal structure of human bleomycin hydrolase C73A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q13867 · AlphaFold monomer V2.0 prediction for bleomycin hydrolase (Q13867) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q13867
Elsewhere: RCSB PDB 7V5S · PDBe 7V5S · UniProt Q13867

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.