MolNFT v1 · #189114 · protein
Protomer structure from the dimer of yeast tho complex
7V2W · Tho complex subunit HPR1: “Protomer structure from the dimer of yeast tho complex”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #189114 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7V2W
- Type
- protein
- Length
- 2,655 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tho complex subunit HPR1; Tho complex subunit 2; Protein TEX1; Tho complex subunit MFT1…
- UniProt
- P17629, P53552, P53851, P33441, O13539
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 5 distinct chains · 49% helix, 7% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Tho complex subunit HPR1 | protein | 593 | 47% helix, 0% strand | P17629 |
| G | Tho complex subunit 2 | protein | 1207 | 57% helix, 2% strand | P53552 |
| H | Protein TEX1 | protein | 379 | 12% helix, 37% strand | P53851 |
| I | Tho complex subunit MFT1 | protein | 240 | 65% helix, 5% strand | P33441 |
| J | Tho complex subunit THP2 | protein | 236 | 52% helix, 1% strand | O13539 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1097 | 0.85 | 0.86 | 98 | empty |
| 2 | 907 | 0.85 | 0.86 | 67 | empty |
| 3 | 1008 | 0.82 | 0.83 | 101 | empty |
| 4 | 826 | 0.81 | 0.84 | 83 | empty |
| 5 | 827 | 0.80 | 0.83 | 64 | empty |
Interfaces
10 interfaces between chains.
- F–G · 7751 Ų buried · 46 hydrogen bonds · protein-protein
- I–J · 5435 Ų buried · 26 hydrogen bonds · protein-protein
- F–J · 2592 Ų buried · 16 hydrogen bonds · protein-protein
- F–I · 2154 Ų buried · 6 hydrogen bonds · protein-protein
- G–H · 2106 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 7V2W · protomer structure from the dimer of yeast THO complex · the same entry in another collection · chain J against J, TM-score 1.00
- P53851 · AlphaFold monomer V2.0 prediction for protein TEX1 (P53851) · a predicted model of the same protein · chain H against A, TM-score 0.95
- P53552 · AlphaFold monomer V2.0 prediction for tho complex subunit 2 (P53552) · a predicted model of the same protein · chain G against A, TM-score 0.84
- P17629 · AlphaFold monomer V2.0 prediction for tho complex subunit HPR1 (P17629) · a predicted model of the same protein · chain F against A, TM-score 0.43
- P33441 · AlphaFold monomer V2.0 prediction for tho complex subunit MFT1 (P33441) · a predicted model of the same protein · chain I against A, TM-score 0.42
- O13539 · AlphaFold monomer V2.0 prediction for tho complex subunit THP2 (O13539) · a predicted model of the same protein · chain J against A, TM-score 0.36
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17629
- Every structure of UniProt P53552
- Every structure of UniProt P53851
- Every structure of UniProt P33441
- Every structure of UniProt O13539
- Elsewhere: RCSB PDB 7V2W · PDBe 7V2W · UniProt P17629 · UniProt P53552 · UniProt P53851 · UniProt P33441 · UniProt O13539
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