MolNFT v1 · #189006 · protein
Structure of the higher-order il-25-il-17RB complex
7UWK · Interleukin-25: “Structure of the higher-order il-25-il-17RB complex”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #189006 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UWK
- Type
- protein
- Length
- 2,059 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-25; Interleukin-17 receptor B
- UniProt
- Q9H293, Q9NRM6
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 8 distinct chains · 4% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, E, F | Interleukin-25 | protein | 96 | 0% helix, 46% strand | Q9H293 |
| C | Interleukin-17 receptor B | protein | 247 | 6% helix, 40% strand | Q9NRM6 |
| B, G, H | Interleukin-25 | protein | 100 | 0% helix, 35% strand | Q9H293 |
| D | Interleukin-17 receptor B | protein | 235 | 3% helix, 36% strand | Q9NRM6 |
| I | Interleukin-17 receptor B | protein | 249 | 4% helix, 38% strand | Q9NRM6 |
| K | Interleukin-17 receptor B | protein | 244 | 3% helix, 34% strand | Q9NRM6 |
| J | Interleukin-17 receptor B | protein | 244 | 5% helix, 39% strand | Q9NRM6 |
| L | Interleukin-17 receptor B | protein | 252 | 5% helix, 33% strand | Q9NRM6 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1169 | 0.86 | 0.87 | 141 | empty |
| 2 | 634 | 0.84 | 0.89 | 91 | empty |
| 3 | 1002 | 0.83 | 0.84 | 122 | empty |
| 4 | 460 | 0.80 | 0.87 | 57 | empty |
| 5 | 327 | 0.77 | 0.89 | 54 | empty |
Interfaces
17 interfaces between chains.
- H–L · 1089 Ų buried · 7 hydrogen bonds · protein-protein
- F–H · 1056 Ų buried · 9 hydrogen bonds · protein-protein
- G–K · 1023 Ų buried · 10 hydrogen bonds · protein-protein
- A–B · 988 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 963 Ų buried · 7 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 41 disulfide (disulfide).
Compared structures
- 7UWK · Structure of the higher-order IL-25-IL-17RB complex · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H293
- Every structure of UniProt Q9NRM6
- Elsewhere: RCSB PDB 7UWK · PDBe 7UWK · UniProt Q9H293 · UniProt Q9NRM6
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