MolNFT v1 · #189001 · protein
Drosophila melanogaster SETDB1-tuor domain with peptide H3K9ME2K14AC
7UVE · Histone-lysine N-methyltransferase eggless: “Drosophila melanogaster SETDB1-tuor domain with peptide H3K9ME2K14AC”. X-ray diffraction, 1 pocket (best druggability 0.49). MolNFT v1 #189001 on GenesisL1: 3D structure, binding sites…
- PDB
- 7UVE
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone-lysine N-methyltransferase eggless; Peptide H3K9ME2K14AC
- EC
- 2.1.1.355
- UniProt
- Q32KD2
- Pockets
- 1 · best druggability 0.49
Structure
x-ray diffraction · 2 distinct chains · 13% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone-lysine N-methyltransferase eggless (EC 2.1.1.355) | protein | 229 | 13% helix, 40% strand | Q32KD2 |
| B | Peptide H3K9ME2K14AC | protein | 7 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.49 | 0.77 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 509 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (acetylation).
Compared structures
- 7UVE · Drosophila melanogaster setdb1-tuor domain with peptide H3K9me2K14ac · the same entry in another collection · chain A against A, TM-score 1.00
- Q32KD2 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase eggless (Q32KD2) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q32KD2
- Elsewhere: RCSB PDB 7UVE · PDBe 7UVE · UniProt Q32KD2
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