MolNFT v1 · #188932 · protein
PRMT5/MEP50 crystal structure with mta and an achiral, class 1, non- atropisomeric inhibitor bound
7UOH: “PRMT5/MEP50 crystal structure with mta and an achiral, class 1, non- atropisomeric inhibitor bound”. X-ray diffraction, 2 ligands (NXF, MTA). MolNFT v1 #188932 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UOH
- Type
- protein
- Length
- 927 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O14744, Q9BQA1
- Ligands
- NXF, MTA
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 625 | — | O14744 |
| B | — | protein | 302 | — | Q9BQA1 |
Ligands and binding sites
- NXF · (2M)-2-[(4M)-4-{4-(aminomethyl)-1-oxo-8-[(2R)-oxolan-2-yl]-1,2-dihydrophthalazin-6-yl}-1-methyl-1H-pyrazol-5-yl]-1-benzothiophene-3-carbonitrile · ligand · chains A
- MTA · 5'-deoxy-5'-methylthioadenosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7UOH · PRMT5/MEP50 crystal structure with MTA and an achiral, class 1, non-atropisomeric… · the same entry in another collection · chain A against A, TM-score 1.00
- O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14744
- Every structure of UniProt Q9BQA1
- Elsewhere: RCSB PDB 7UOH · PDBe 7UOH · UniProt O14744 · UniProt Q9BQA1
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