MolNFT v1 · #188888 · protein
Human KV4.2-KCHIP2-DPP6 channel complex in an open state, transmembrane region
7UKG · Potassium voltage-gated channel subfamily D member 2: “Human KV4.2-KCHIP2-DPP6 channel complex in an open state, transmembrane region”. Electron microscopy, 1 ligand (K), 17 pockets (best druggability 0.81). MolNFT v1 #188888 on…
- PDB
- 7UKG
- Type
- protein
- Length
- 1,128 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily D member 2; Dipeptidyl-peptidase 6
- UniProt
- Q9NZV8, A7E2E4
- Ligands
- K
- Pockets
- 17 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 77% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Potassium voltage-gated channel subfamily D member 2 | protein | 259 | 76% helix, 3% strand | Q9NZV8 |
| I, J, K, L | Dipeptidyl-peptidase 6 | protein | 23 | 91% helix, 0% strand | A7E2E4 |
Ligands and binding sites
- K · Potassium ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
17 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 824 | 0.81 | 0.84 | 41 | empty |
| 2 | 633 | 0.67 | 0.75 | 64 | empty |
| 3 | 535 | 0.65 | 0.76 | 49 | empty |
| 4 | 544 | 0.65 | 0.75 | 45 | empty |
| 5 | 528 | 0.65 | 0.76 | 49 | empty |
Interfaces
10 interfaces between chains.
- A–B · 1505 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 1503 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 1501 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 1499 Ų buried · 6 hydrogen bonds · protein-protein
- A–I · 520 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7UKG · Human Kv4.2-KChIP2-DPP6 channel complex in an open state, transmembrane region · the same entry in another collection · chain L against L, TM-score 1.00
- Q9NZV8 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily D member… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZV8
- Every structure of UniProt A7E2E4
- Elsewhere: RCSB PDB 7UKG · PDBe 7UKG · UniProt Q9NZV8 · UniProt A7E2E4
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