MolNFT v1 · #188880 · protein
Estrogen receptor alpha ligand binding domain Y537S mutant in complex with a methylated lasofoxifene derivative that possesses selective estrogen receptor degrader activities
7UJW: “Estrogen receptor alpha ligand binding domain Y537S mutant in complex with a methylated lasofoxifene…”. X-ray diffraction, 1 ligand (R3V). MolNFT v1 #188880 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7UJW
- Type
- protein
- Length
- 848 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03372
- Ligands
- R3V
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | — | protein | 212 | — | P03372 |
| D | — | protein | 218 | — | P03372 |
| C | — | protein | 208 | — | P03372 |
| A | — | protein | 210 | — | P03372 |
Ligands and binding sites
- R3V · (5R,6S)-5-(4-{2-[(3S)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol · ligand · 4 copies · chains B, D, C, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7UJW · Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with a Methylated… · the same entry in another collection · chain A against A, TM-score 1.00
- P03372 · AlphaFold monomer V2.0 prediction for estrogen receptor (P03372) · a predicted model of the same protein · chain C against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03372
- Elsewhere: RCSB PDB 7UJW · PDBe 7UJW · UniProt P03372
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