GL1X · GenesisL1 explorer

MolNFT v1 · #188590 · protein

Structure of murine LAG3 domains 1-2

7TZE · Lymphocyte activation gene 3 protein: “Structure of murine LAG3 domains 1-2”. X-ray diffraction, 1 ligand (NAG), 2 pockets (best druggability 0.47). MolNFT v1 #188590 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB
7TZE
Type
protein
Length
416 residues
Chains
2
Method
x-ray diffraction
Collection
MolNFT v1 / PDB
Contract
0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner
0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule
Lymphocyte activation gene 3 protein
UniProt
Q61790
Ligands
NAG
Pockets
2 · best druggability 0.47

Structure

x-ray diffraction · 2 distinct chains · 7% helix, 47% strand (DSSP).

ChainMoleculeTypeResiduesSecondary structureUniProt
ALymphocyte activation gene 3 proteinprotein2037% helix, 48% strandQ61790
CLymphocyte activation gene 3 proteinprotein2136% helix, 47% strandQ61790

Ligands and binding sites

  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 4 copies · chains A, C
  • EDO · 1,2-ethanediol · additive · 2 copies · chains C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

PocketVolume (ų)DruggabilityBuriednessLining residuesInside
11360.470.7821empty
21760.440.7425empty

Interfaces

1 interface between chains.

  • A–C · 456 Ų buried · 0 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 4 disulfide, 4 glycan (disulfide, N-glycosylation).

Compared structures

  • 7TZE · Structure of murine LAG3 domains 1-2 · the same entry in another collection · chain A against A, TM-score 1.00
  • Q61790 · AlphaFold monomer V2.0 prediction for lymphocyte activation gene 3 protein (Q61790) · a predicted model of the same protein · chain C against A, TM-score 0.90

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