UniProt Q61790
Lymphocyte activation gene 3 protein (Q61790)
Lymphocyte activation gene 3 protein (UniProt Q61790): 6 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 22 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q61790
- Protein
- Lymphocyte activation gene 3 protein
- Experimental structures
- 6
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 22 · 3 records with a druggable one
Structures
7 records of Q61790 in the MolNFT archive: 6 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7TZE | Structure of murine LAG3 domains 1-2 | x-ray diffraction | A, C | NAG | 2 (best 0.47) |
| 7TZE | Structure of murine LAG3 domains 1-2 | x-ray diffraction | A, C | NAG | — |
| 8DGG | Structure of glycosylated LAG-3 homodimer | x-ray diffraction | A, B | NAG, FUC | 8 (best 0.53) |
| 8DGG | Structure of glycosylated lag-3 homodimer | x-ray diffraction | A, B | NAG, FUC | — |
| 9CYL | Structure of LAG3 loop1 deletion bound to the MHC class II molecule I-A(b) | x-ray diffraction | L | NAG | 5 (best 0.77) |
| 9CYM | Structure of LAG3 bound to the MHC class II molecule I-A(b) | x-ray diffraction | L | NAG | 4 (best 0.78) |
| Q61790 | AlphaFold monomer V2.0 prediction for lymphocyte activation gene 3 protein (Q61790) | predicted | A | — | 3 (best 0.43) |
Ligands
Experiment against prediction
- 9CYL chain L against the predicted model Q61790: TM-score 0.93, RMSD 1.47 Å
- 9CYM chain L against the predicted model Q61790: TM-score 0.92, RMSD 1.88 Å
- 7TZE chain C against the predicted model Q61790: TM-score 0.90, RMSD 2.02 Å
- 7TZE chain C against the predicted model Q61790: TM-score 0.90, RMSD 2.02 Å
- 7TZE chain A against the predicted model Q61790: TM-score 0.84, RMSD 2.79 Å
- 7TZE chain A against the predicted model Q61790: TM-score 0.84, RMSD 2.79 Å
- 8DGG chain B against the predicted model Q61790: TM-score 0.72, RMSD 3.79 Å
- 8DGG chain B against the predicted model Q61790: TM-score 0.72, RMSD 3.78 Å
- 8DGG chain A against the predicted model Q61790: TM-score 0.64, RMSD 4.00 Å
- 8DGG chain A against the predicted model Q61790: TM-score 0.64, RMSD 4.01 Å
Elsewhere
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