MolNFT v1 · #188582 · protein

Structure of human fibrinogen-like protein 1

7TZ2: “Structure of human fibrinogen-like protein 1”. X-ray diffraction, 1 ligand (CA), 13 pockets (best druggability 0.77). MolNFT v1 #188582 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7TZ2
Type: protein
Length: 682 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fibrinogen-like protein 1
UniProt: Q08830
Ligands: CA
Pockets: 13 · best druggability 0.77

Structure

x-ray diffraction · 3 distinct chains · 13% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fibrinogen-like protein 1	protein	220	12% helix, 31% strand	Q08830
B	Fibrinogen-like protein 1	protein	231	15% helix, 28% strand	Q08830
C	Fibrinogen-like protein 1	protein	231	12% helix, 30% strand	Q08830

Ligands and binding sites

CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	637	0.77	0.83	79	empty
2	270	0.70	0.85	41	empty
3	55	0.56	0.89	17	empty
4	78	0.54	0.86	24	empty
5	82	0.47	0.82	26	empty

Interfaces

3 interfaces between chains.

B–C · 997 Å² buried · 10 hydrogen bonds · protein-protein
A–C · 464 Å² buried · 2 hydrogen bonds · protein-protein
A–B · 379 Å² buried · 7 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

7TZ2 · Structure of human Fibrinogen-like protein 1 · the same entry in another collection · chain B against B, TM-score 1.00
Q08830 · AlphaFold monomer V2.0 prediction for fibrinogen-like protein 1 (Q08830) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q08830
Elsewhere: RCSB PDB 7TZ2 · PDBe 7TZ2 · UniProt Q08830

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