MolNFT v1 · #188512 · protein
Hyperlytic variant of TAE1, type VI secretion amidase effector 1, from pseudomonas aeruginosa (CYS110SER)
7TVH · Peptidoglycan amidase TSE1: “Hyperlytic variant of TAE1, type VI secretion amidase effector 1, from pseudomonas aeruginosa (CYS110SER)”. X-ray diffraction, 4 pockets (best druggability 0.67). MolNFT v1 #188512 on GenesisL1: 3D…
- PDB
- 7TVH
- Type
- protein
- Length
- 584 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidoglycan amidase TSE1
- EC
- 3.4.19.11
- UniProt
- Q9I2Q1
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 145 | 38% helix, 21% strand | Q9I2Q1 |
| B, D | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 146 | 38% helix, 21% strand | Q9I2Q1 |
| C | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 147 | 38% helix, 20% strand | Q9I2Q1 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 746 | 0.67 | 0.75 | 88 | empty |
| 2 | 79 | 0.53 | 0.85 | 27 | empty |
| 3 | 79 | 0.51 | 0.84 | 29 | empty |
| 4 | 78 | 0.28 | 0.72 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 694 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 689 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 381 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 370 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 50 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7TVH · Hyperlytic variant of Tae1, Type VI secretion amidase effector 1, from Pseudomonas… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I2Q1 · AlphaFold monomer V2.0 prediction for peptidoglycan amidase TSE1 (Q9I2Q1) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I2Q1
- Elsewhere: RCSB PDB 7TVH · PDBe 7TVH · UniProt Q9I2Q1
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