Research workbench
Hyperlytic variant of TAE1, type VI secretion amidase effector 1, from pseudomonas aeruginosa (CYS110SER)
Analyse Hyperlytic variant of TAE1, type VI secretion amidase effector 1, from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7TVH
- Type
- protein
- Length
- 584 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Peptidoglycan amidase TSE1
- EC
- 3.4.19.11
- UniProt
- Q9I2Q1
- Pockets
- 4 · best druggability 0.67
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 145 | 38% helix, 21% strand | Q9I2Q1 |
| B, D | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 146 | 38% helix, 21% strand | Q9I2Q1 |
| C | Peptidoglycan amidase TSE1 (EC 3.4.19.11) | protein | 147 | 38% helix, 20% strand | Q9I2Q1 |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 746 | 0.67 | 0.75 | 88 | empty |
| 2 | 79 | 0.53 | 0.85 | 27 | empty |
| 3 | 79 | 0.51 | 0.84 | 29 | empty |
| 4 | 78 | 0.28 | 0.72 | 17 | empty |
Interfaces
5 interfaces between chains.
- A–B · 694 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 689 Ų buried · 6 hydrogen bonds · protein-protein
- A–D · 381 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 370 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 50 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 7TVH · Hyperlytic variant of Tae1, Type VI secretion amidase effector 1, from Pseudomonas… · the same entry in another collection · chain A against A, TM-score 1.00
- Q9I2Q1 · AlphaFold monomer V2.0 prediction for peptidoglycan amidase TSE1 (Q9I2Q1) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9I2Q1
- Elsewhere: RCSB PDB 7TVH · PDBe 7TVH · UniProt Q9I2Q1
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