MolNFT v1 · #188462 · protein
Bamabcde bound to substrate espp class 6
7TT4 · Outer membrane protein assembly factor bama: “Bamabcde bound to substrate espp class 6”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #188462 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TT4
- Type
- protein
- Length
- 1,346 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Outer membrane protein assembly factor bama; MALTOSE/MALTODEXTRIN-binding periplasmic…
- EC
- 3.4.21.-
- UniProt
- C3TPJ2, Q7BSW5, A0A1X3I1M6, W8SZY2, A0A3L5AP29, A0A507WQ69
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 6 distinct chains · 20% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Outer membrane protein assembly factor bama | protein | 621 | 14% helix, 45% strand | C3TPJ2 |
| P | MALTOSE/MALTODEXTRIN-binding periplasmic PROTEIN,SERINE protease espp chimera (EC 3.4.21.-) | protein | 25 | 0% helix, 48% strand | Q7BSW5 |
| D | Outer membrane protein assembly factor bamd | protein | 213 | 77% helix, 0% strand | A0A1X3I1M6 |
| C | Outer membrane protein assembly factor bamc | protein | 48 | 15% helix, 0% strand | W8SZY2 |
| E | Outer membrane protein assembly factor bame | protein | 89 | 20% helix, 35% strand | A0A3L5AP29 |
| B | Outer membrane protein assembly factor bamb | protein | 350 | 0% helix, 46% strand | A0A507WQ69 |
Pockets
20 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 396 | 0.81 | 0.90 | 65 | empty |
| 2 | 855 | 0.80 | 0.83 | 90 | empty |
| 3 | 155 | 0.62 | 0.85 | 39 | empty |
| 4 | 330 | 0.58 | 0.76 | 42 | empty |
| 5 | 279 | 0.57 | 0.77 | 32 | empty |
Interfaces
8 interfaces between chains.
- D–C · 1822 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 1000 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 859 Ų buried · 19 hydrogen bonds · protein-protein
- A–E · 849 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 826 Ų buried · 8 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C3TPJ2
- Every structure of UniProt Q7BSW5
- Every structure of UniProt A0A1X3I1M6
- Every structure of UniProt W8SZY2
- Every structure of UniProt A0A3L5AP29
- Every structure of UniProt A0A507WQ69
- Elsewhere: RCSB PDB 7TT4 · PDBe 7TT4 · UniProt C3TPJ2 · UniProt Q7BSW5 · UniProt A0A1X3I1M6 · UniProt W8SZY2 · UniProt A0A3L5AP29 · UniProt A0A507WQ69
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