MolNFT v1 · #188448 · protein
Structure of human endothelial nitric oxide synthase heme domain in complex with 4-methyl-6-(3-(METHYLAMINO)PROPYL)PYRIDIN-2-amine
7TSH: “Structure of human endothelial nitric oxide synthase heme domain in complex with…”. X-ray diffraction, 6 ligands (HEM, H4B, KKU). MolNFT v1 #188448 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7TSH
- Type
- protein
- Length
- 1,606 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P29474
- Ligands
- HEM, H4B, KKU, GD, ZN, CL
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 400 | — | P29474 |
| B, D | — | protein | 402 | — | P29474 |
| C | — | protein | 402 | — | P29474 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 4 copies · chains A, B, C, D
- H4B · 5,6,7,8-tetrahydrobiopterin · ligand · 4 copies · chains A, B, C, D
- KKU · 4-methyl-6-[3-(methylamino)propyl]pyridin-2-amine · ligand · 4 copies · chains A, B, C, D
- GD · Gadolinium atom · metal · 4 copies · chains B, D
- ZN · Zinc ion · metal · 2 copies · chains A, B, C, D
- CL · Chloride ion · ion · 4 copies · chains A, B, C, D
- BTB · 2-[bis-(2-hydroxy-ethyl)-amino]-2-hydroxymethyl-propane-1,3-diol · additive · 10 copies · chains A, B, C, D
- GOL · Glycerol · additive · 8 copies · chains A, C, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7TSH · Structure of human endothelial nitric oxide synthase heme domain in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P29474
- Elsewhere: RCSB PDB 7TSH · PDBe 7TSH · UniProt P29474
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