MolNFT v1 · #188411 · protein

Structure of human TREX1

7TQO · Three-prime repair exonuclease 1: “Structure of human TREX1”. X-ray diffraction, 1 pocket (best druggability 0.45). MolNFT v1 #188411 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7TQO
Type: protein
Length: 225 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Three-prime repair exonuclease 1
EC: 3.1.11.2
UniProt: Q9NSU2
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 1 distinct chain · 40% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Three-prime repair exonuclease 1 (EC 3.1.11.2)	protein	225	40% helix, 16% strand	Q9NSU2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	149	0.45	0.76	28	empty

Compared structures

7TQO · Structure of human TREX1 · the same entry in another collection · chain A against A, TM-score 1.00
Q9NSU2 · AlphaFold monomer V2.0 prediction for three-prime repair exonuclease 1 (Q9NSU2) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NSU2
Elsewhere: RCSB PDB 7TQO · PDBe 7TQO · UniProt Q9NSU2

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