MolNFT v1 · #18828 · protein
Structure and autoregulation of the yeast HST2 homolog of SIR2
1Q14 · HST2 protein: “Structure and autoregulation of the yeast HST2 homolog of SIR2”. X-ray diffraction, 2 ligands (ZN, CL), 3 pockets (best druggability 0.57). MolNFT v1 #18828 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 1Q14
- Type
- protein
- Length
- 289 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HST2 protein
- UniProt
- P53686
- Ligands
- ZN, CL
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HST2 protein | protein | 289 | 42% helix, 16% strand | P53686 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 292 | 0.57 | 0.77 | 40 | empty |
| 2 | 77 | 0.33 | 0.75 | 18 | empty |
| 3 | 71 | 0.31 | 0.75 | 19 | empty |
Compared structures
- 1Q14 · Structure and autoregulation of the yeast Hst2 homolog of Sir2 · the same entry in another collection · chain A against A, TM-score 1.00
- P53686 · AlphaFold monomer V2.0 prediction for NAD-dependent protein deacetylase HST2 (P53686) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53686
- Elsewhere: RCSB PDB 1Q14 · PDBe 1Q14 · UniProt P53686
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.