MolNFT v1 · #188026 · protein
MUNC13-1 C1-C2B-mun-C2C upright conformation spanning two lipid bilayers
7T7X · Protein unc-13 homolog a: “MUNC13-1 C1-C2B-mun-C2C upright conformation spanning two lipid bilayers”. Electron microscopy, 4 pockets (best druggability 0.55). MolNFT v1 #188026 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7T7X
- Type
- protein
- Length
- 1,132 residues
- Chains
- 1
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein unc-13 homolog a
- UniProt
- Q62768, Q4KUS2
- Pockets
- 4 · best druggability 0.55
Structure
electron microscopy · 1 distinct chain · 54% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein unc-13 homolog a | protein | 1132 | 54% helix, 14% strand | Q62768, Q4KUS2 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 52 | 0.55 | 0.89 | 20 | empty |
| 2 | 315 | 0.53 | 0.75 | 36 | empty |
| 3 | 94 | 0.36 | 0.74 | 18 | empty |
| 4 | 62 | 0.28 | 0.73 | 19 | empty |
Compared structures
- 7T7X · Munc13-1 C1-C2B-MUN-C2C Upright conformation spanning two lipid bilayers · the same entry in another collection · chain A against A, TM-score 1.00
- Q62768 · AlphaFold monomer V2.0 prediction for protein unc-13 homolog a (Q62768) · a predicted model of the same protein · chain A against A, TM-score 0.74
- Q4KUS2 · AlphaFold monomer V2.0 prediction for protein unc-13 homolog a (Q4KUS2) · a predicted model of the same protein · chain A against A, TM-score 0.74
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q62768
- Every structure of UniProt Q4KUS2
- Elsewhere: RCSB PDB 7T7X · PDBe 7T7X · UniProt Q62768 · UniProt Q4KUS2
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.