UniProt Q4KUS2
Protein unc-13 homolog A (Q4KUS2)
Protein unc-13 homolog A (UniProt Q4KUS2): 8 experimental structures and 1 predicted model on GenesisL1, 79 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q4KUS2
- Protein
- Protein unc-13 homolog A
- Experimental structures
- 8
- Predicted models
- 1
- Pockets
- 79 · 6 records with a druggable one
Structures
9 records of Q4KUS2 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7T7C | The hexagonal organization of Munc13-1 C1-C2B-MUN-C2C domains between lipid bilayers | electron microscopy | A, B, C, D, E, F, G, H, I, J, K, L | — | 20 (best 0.81) |
| 7T7R | Structure of Munc13-1 C1-C2B-MUN-C2C trimer between lipid bilayers | electron microscopy | A, B, C | — | 10 (best 0.55) |
| 7T7R | Structure of MUNC13-1 C1-C2B-mun-C2C trimer between lipid bilayers | electron microscopy | A, B, C | — | — |
| 7T7V | Munc13-1 C1-C2B-MUN-C2C Lateral conformation on lipid bilayer surface | electron microscopy | A | — | 11 (best 0.61) |
| 7T7V | MUNC13-1 C1-C2B-mun-C2C lateral conformation on lipid bilayer surface | electron microscopy | A | — | — |
| 7T7X | Munc13-1 C1-C2B-MUN-C2C Upright conformation spanning two lipid bilayers | electron microscopy | A | — | 4 (best 0.55) |
| 7T7X | MUNC13-1 C1-C2B-mun-C2C upright conformation spanning two lipid bilayers | electron microscopy | A | — | — |
| 7T81 | Model of Munc13-1 C1-C2B-MUN-C2C 2D crystal between lipid bilayers. | electron microscopy | A, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y | — | 20 (best 0.81) |
| Q4KUS2 | AlphaFold monomer V2.0 prediction for protein unc-13 homolog a (Q4KUS2) | predicted | A | — | 14 (best 0.83) |
Experiment against prediction
- 7T81 chain C against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain F against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain G against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T7V chain A against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T7V chain A against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T7C chain A against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain A against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain D against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain E against the predicted model Q4KUS2: TM-score 0.84, RMSD 4.62 Å
- 7T81 chain F against the predicted model Q62768: TM-score 0.82, RMSD 5.05 Å
Elsewhere
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