MolNFT v1 · #18777 · protein
Crystal structure of hgprt-ase from leishmania tarentolae in complex with gmp
1PZM · Hypoxanthine-guanine phosphoribosyltransferase: “Crystal structure of hgprt-ase from leishmania tarentolae in complex with gmp”. X-ray diffraction, 1 ligand (5GP), 2 pockets (best druggability 0.52). MolNFT v1 #18777 on GenesisL1…
- PDB
- 1PZM
- Type
- protein
- Length
- 340 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypoxanthine-guanine phosphoribosyltransferase
- EC
- 2.4.2.8
- UniProt
- Q9NJI5
- Ligands
- 5GP
- Pockets
- 2 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 170 | 29% helix, 32% strand | Q9NJI5 |
| B | Hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) | protein | 170 | 32% helix, 31% strand | Q9NJI5 |
Ligands and binding sites
- 5GP · Guanosine-5'-monophosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 242 | 0.52 | 0.76 | 37 | 5GP |
| 2 | 153 | 0.43 | 0.75 | 26 | 5GP |
Interfaces
1 interface between chains.
- A–B · 1436 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 1PZM · Crystal structure of HGPRT-ase from Leishmania tarentolae in complex with GMP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NJI5
- Elsewhere: RCSB PDB 1PZM · PDBe 1PZM · UniProt Q9NJI5
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