MolNFT v1 · #187715 · protein
Structure of human KV1.3 (alternate conformation)
7SSY · Potassium voltage-gated channel subfamily a member 3,GREEN…: “Structure of human KV1.3 (alternate conformation)”. Electron microscopy, 1 ligand (K), 20 pockets (best druggability 0.85). MolNFT v1 #187715 on GenesisL1: 3D structure…
- PDB
- 7SSY
- Type
- protein
- Length
- 1,384 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium voltage-gated channel subfamily a member 3,GREEN fluorescent protein fusion
- UniProt
- P22001
- Ligands
- K
- Pockets
- 20 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Potassium voltage-gated channel subfamily a member 3,GREEN fluorescent protein fusion | protein | 346 | 63% helix, 5% strand | P22001 |
Ligands and binding sites
- K · Potassium ion · metal · 3 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1128 | 0.85 | 0.85 | 105 | empty |
| 2 | 921 | 0.80 | 0.82 | 40 | empty |
| 3 | 346 | 0.61 | 0.77 | 29 | empty |
| 4 | 354 | 0.61 | 0.76 | 34 | empty |
| 5 | 349 | 0.60 | 0.76 | 27 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2459 Ų buried · 21 hydrogen bonds · protein-protein
- A–B · 2457 Ų buried · 21 hydrogen bonds · protein-protein
- A–D · 2457 Ų buried · 21 hydrogen bonds · protein-protein
- B–C · 2452 Ų buried · 21 hydrogen bonds · protein-protein
- B–D · 16 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7SSY · Structure of human Kv1.3 (alternate conformation) · the same entry in another collection · chain D against D, TM-score 1.00
- P22001 · AlphaFold monomer V2.0 prediction for potassium voltage-gated channel subfamily a member… · a predicted model of the same protein · chain D against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P22001
- Elsewhere: RCSB PDB 7SSY · PDBe 7SSY · UniProt P22001
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.