MolNFT v1 · #187683 · protein
Cryo-EM structure of mouse agonist ml-SA1-bound TRPML1 channel at 2.32 ångström resolution
7SQ6: “Cryo-EM structure of mouse agonist ml-SA1-bound TRPML1 channel at 2.32 ångström resolution”. Electron microscopy, 3 ligands (AQV, NAG, NA). MolNFT v1 #187683 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SQ6
- Type
- protein
- Length
- 1,868 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q99J21
- Ligands
- AQV, NAG, NA
Structure
electron microscopy · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | — | protein | 467 | — | Q99J21 |
Ligands and binding sites
- AQV · 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione · ligand · 4 copies · chains A, D, B, C
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B, C, D
- NA · Sodium ion · metal · 2 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7SQ6 · Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
- Q99J21 · AlphaFold monomer V2.0 prediction for mucolipin-1 (Q99J21) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99J21
- Elsewhere: RCSB PDB 7SQ6 · PDBe 7SQ6 · UniProt Q99J21
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