UniProt Q99J21
Mucolipin-1 (Q99J21)
Mucolipin-1 (UniProt Q99J21): 17 experimental structures and 1 predicted model on GenesisL1, 5 ligands bound, 60 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q99J21
- Protein
- Mucolipin-1
- Experimental structures
- 17
- Predicted models
- 1
- Ligands
- 5
- Pockets
- 60 · 3 records with a druggable one
Structures
18 records of Q99J21 in the MolNFT archive: 17 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5WPQ | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation… | electron microscopy | A, B, C, D | NAG | 20 (best 0.84) |
| 5WPQ | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation… | electron microscopy | A, B, C, D | NAG | — |
| 5WPT | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation… | electron microscopy | A, B, C, D | NAG | — |
| 5WPV | Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 ångström resolution | electron microscopy | A, B, C, D | NAG | — |
| 5YDZ | structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 1 | electron microscopy | A, B, C, D | — | — |
| 5YDZ | Structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 1 | electron microscopy | A, B, C, D | — | — |
| 5YE1 | structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 2 | electron microscopy | A, B, C, D | — | — |
| 5YE1 | Structure of endo-lysosomal TRPML1 channel inserting into amphipol: state 2 | electron microscopy | A, B, C, D | — | — |
| 5YE2 | Mammalian endo-lysosomal TRPML1 channel inserting into amphipol | electron microscopy | A, B, C, D | — | — |
| 5YE5 | structure of endo-lysosomal TRPML1 channel inserting into nanodisc | electron microscopy | A, B, C, D | NAG | — |
| 5YE5 | Structure of endo-lysosomal TRPML1 channel inserting into nanodisc | electron microscopy | A, B, C, D | NAG | — |
| 7SQ6 | Cryo-EM structure of mouse agonist ml-SA1-bound TRPML1 channel at 2.32 ångström resolution | electron microscopy | A, B, C, D | NAG, AQV, NA | — |
| 7SQ7 | Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution | electron microscopy | A, B, C, D | NAG, EUJ, NA | 20 (best 0.88) |
| 7SQ7 | Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 ångström resolution | electron microscopy | A, B, C, D | NAG, EUJ, NA | — |
| 7SQ8 | Cryo-EM structure of mouse apo TRPML1 channel at 2.598 ångström resolution | electron microscopy | A, B, C, D | NAG, NA | — |
| 7SQ9 | Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution | electron microscopy | A, B, C, D | NAG, EUJ, A4I, NA | 20 (best 0.83) |
| 7SQ9 | Cryo-EM structure of mouse TEMSIROLIMUS/PI(3,5)P2-bound TRPML1 channel at 2.11 ångström resolution | electron microscopy | A, B, C, D | NAG, EUJ, A4I, NA | — |
| Q99J21 | AlphaFold monomer V2.0 prediction for mucolipin-1 (Q99J21) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 12 records
- NA · Sodium ion · in 6 records
- EUJ · (2R)-3-{[(S)-hydroxy{[(1s,2r,3r,4s,5s,6r)-2,4,6-trihydroxy-3,5-bis(phosphonooxy) cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate · in 4 records
- A4I · (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E, 19e,21s,23s,26r,27r,30s,34as)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26, 27,28,29,31,32,33,34,34A-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate · in 2 records
- AQV · 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione · in 1 record
Experiment against prediction
- 7SQ8 chain A against the predicted model Q99J21: TM-score 0.98, RMSD 1.22 Å
- 7SQ7 chain D against the predicted model Q99J21: TM-score 0.98, RMSD 1.27 Å
- 7SQ7 chain A against the predicted model Q99J21: TM-score 0.98, RMSD 1.27 Å
- 7SQ7 chain A against the predicted model Q99J21: TM-score 0.98, RMSD 1.27 Å
- 7SQ7 chain B against the predicted model Q99J21: TM-score 0.98, RMSD 1.27 Å
- 7SQ7 chain C against the predicted model Q99J21: TM-score 0.98, RMSD 1.27 Å
- 5WPQ chain C against the predicted model Q99J21: TM-score 0.96, RMSD 1.63 Å
- 5WPQ chain B against the predicted model Q99J21: TM-score 0.96, RMSD 1.63 Å
- 5WPQ chain A against the predicted model Q99J21: TM-score 0.96, RMSD 1.63 Å
- 5WPQ chain A against the predicted model Q99J21: TM-score 0.96, RMSD 1.63 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.