MolNFT v1 · #187558 · protein
Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab
7SK5: “Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab”. Electron microscopy, 1 ligand (CLR). MolNFT v1 #187558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SK5
- Type
- protein
- Length
- 897 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P25106, P48061
- Ligands
- CLR
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 300 | — | P25106 |
| F | — | protein | 220 | — | — |
| B | — | protein | 63 | — | P48061 |
| E | — | protein | 211 | — | — |
| K | — | protein | 103 | — | — |
Ligands and binding sites
- CLR · Cholesterol · ligand · 7 copies · chains A, F
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7SK5 · Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab · the same entry in another collection · chain F against F, TM-score 1.00
- P25106 · AlphaFold monomer V2.0 prediction for atypical chemokine receptor 3 (P25106) · a predicted model of the same protein · chain A against A, TM-score 0.93
- P48061 · AlphaFold monomer V2.0 prediction for stromal cell-derived factor 1 (P48061) · a predicted model of the same protein · chain B against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P25106
- Every structure of UniProt P48061
- Elsewhere: RCSB PDB 7SK5 · PDBe 7SK5 · UniProt P25106 · UniProt P48061
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