MolNFT v1 · #187554 · protein
TWIK1 in MSP1E3D1 lipid nanodisc at pH 5.5
7SK1 · Potassium channel subfamily K member 1: “TWIK1 in MSP1E3D1 lipid nanodisc at pH 5.5”. Electron microscopy, 2 ligands (C14, K), 9 pockets (best druggability 0.80). MolNFT v1 #187554 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7SK1
- Type
- protein
- Length
- 524 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Potassium channel subfamily K member 1
- UniProt
- Q9Z2T2
- Ligands
- C14, K
- Pockets
- 9 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Potassium channel subfamily K member 1 | protein | 262 | 78% helix, 0% strand | Q9Z2T2 |
Ligands and binding sites
- C14 · Tetradecane · ligand · 2 copies · chains A, B
- K · Potassium ion · metal · 3 copies · chains A, B
- OCT · N-octane · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 939 | 0.80 | 0.81 | 64 | C14 |
| 2 | 442 | 0.71 | 0.82 | 51 | empty |
| 3 | 432 | 0.70 | 0.81 | 49 | empty |
| 4 | 88 | 0.43 | 0.79 | 19 | empty |
| 5 | 99 | 0.42 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 6078 Ų buried · 30 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9Z2T2
- Elsewhere: RCSB PDB 7SK1 · PDBe 7SK1 · UniProt Q9Z2T2
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