MolNFT v1 · #187534 · protein
Crystal structure of voltage gated potassium ion channel, kv 1.2 chimera-3M
7SIT · Voltage-gated potassium channel subunit beta-2: “Crystal structure of voltage gated potassium ion channel, kv 1.2 chimera-3M”. X-ray diffraction, 3 ligands (NAP, K, O), 13 pockets (best druggability 0.75). MolNFT v1 #187534 on…
- PDB
- 7SIT
- Type
- protein
- Length
- 1,302 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Voltage-gated potassium channel subunit beta-2; Voltage gated potassium channel…
- EC
- 1.1.1.-
- UniProt
- P62483
- Ligands
- NAP, K, O
- Pockets
- 13 · best druggability 0.75
Structure
x-ray diffraction · 3 distinct chains · 55% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) | protein | 326 | 48% helix, 15% strand | P62483 |
| B | Voltage gated potassium channel KV1.2-KV2.1 | protein | 325 | 58% helix, 6% strand | — |
| D | Voltage gated potassium channel KV1.2-KV2.1 | protein | 325 | 59% helix, 6% strand | — |
Ligands and binding sites
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · ligand · 2 copies · chains A, C
- K · Potassium ion · metal · 4 copies · chains B, D
- O · Oxygen atom · ion · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 270 | 0.75 | 0.88 | 36 | NAP |
| 2 | 349 | 0.72 | 0.84 | 56 | NAP |
| 3 | 68 | 0.60 | 0.90 | 18 | empty |
| 4 | 122 | 0.52 | 0.81 | 25 | empty |
| 5 | 54 | 0.43 | 0.83 | 14 | empty |
Interfaces
2 interfaces between chains.
- A–B · 423 Ų buried · 5 hydrogen bonds · protein-protein
- C–D · 422 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 7SIT · Crystal structure of Voltage gated potassium ion channel, Kv 1.2 chimera-3m · the same entry in another collection · chain A against A, TM-score 1.00
- P62483 · AlphaFold monomer V2.0 prediction for voltage-gated potassium channel subunit beta-2… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62483
- Elsewhere: RCSB PDB 7SIT · PDBe 7SIT · UniProt P62483
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