MolNFT v1 · #187471 · protein

Crystal structure of olmo, a spirocyclase involved in the biosynthesis of oligomycin

7SFN · Olmo - oligomycin spirocyclase: “Crystal structure of olmo, a spirocyclase involved in the biosynthesis of oligomycin”. X-ray diffraction, 1 ligand (MLT), 3 pockets (best druggability 0.70). MolNFT v1 #187471 on GenesisL1: 3D…

PDB: 7SFN
Type: protein
Length: 301 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Olmo - oligomycin spirocyclase
UniProt: Q93HI7
Ligands: MLT
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 61% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Olmo - oligomycin spirocyclase	protein	148	10% helix, 62% strand	Q93HI7
B	Olmo - oligomycin spirocyclase	protein	153	12% helix, 59% strand	Q93HI7

Ligands and binding sites

MLT · D-malate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	612	0.70	0.78	59	empty
2	397	0.69	0.81	34	empty
3	51	0.32	0.78	15	empty

Interfaces

1 interface between chains.

A–B · 1218 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

7SFN · Crystal structure of OlmO, a spirocyclase involved in the biosynthesis of oligomycin · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q93HI7
Elsewhere: RCSB PDB 7SFN · PDBe 7SFN · UniProt Q93HI7

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