MolNFT v1 · #187448 · protein

PRMT5/MEP50 with compound 29 bound

7SES: “PRMT5/MEP50 with compound 29 bound”. X-ray diffraction, 2 ligands (97X, MTA). MolNFT v1 #187448 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SES
Type: protein
Length: 930 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O14744, Q9BQA1
Ligands: 97X, MTA

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	625	—	O14744
B	—	protein	305	—	Q9BQA1

Ligands and binding sites

97X · (2P)-2-{4-[4-(aminomethyl)-1-oxo-1,2-dihydrophthalazin-6-yl]-1-methyl-1H-pyrazol-5-yl}naphthalene-1-carbonitrile · ligand · chains A
MTA · 5'-deoxy-5'-methylthioadenosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7SES · PRMT5/MEP50 with compound 29 bound · the same entry in another collection · chain A against A, TM-score 1.00
O14744 · AlphaFold monomer V2.0 prediction for protein arginine N-methyltransferase 5 (O14744) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O14744
Every structure of UniProt Q9BQA1
Elsewhere: RCSB PDB 7SES · PDBe 7SES · UniProt O14744 · UniProt Q9BQA1

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