MolNFT v1 · #187348 · protein

Human MUC16 SEA5 domain

7SA9 · Mucin-16: “Human MUC16 SEA5 domain”. X-ray diffraction, 1 pocket (best druggability 0.57). MolNFT v1 #187348 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7SA9
Type: protein
Length: 242 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Mucin-16
UniProt: Q8WXI7
Pockets: 1 · best druggability 0.57

Structure

x-ray diffraction · 2 distinct chains · 33% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Mucin-16	protein	122	33% helix, 32% strand	Q8WXI7
B	Mucin-16	protein	120	33% helix, 34% strand	Q8WXI7

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	297	0.57	0.77	43	empty

Interfaces

1 interface between chains.

A–B · 447 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

7SA9 · Human MUC16 SEA5 Domain · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WXI7
Elsewhere: RCSB PDB 7SA9 · PDBe 7SA9 · UniProt Q8WXI7

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