MolNFT v1 · #187346 · protein
Crystal structure of the apo SH2 domains of syk
7SA7 · Tyrosine-protein kinase syk: “Crystal structure of the apo SH2 domains of syk”. X-ray diffraction, 20 pockets (best druggability 0.70). MolNFT v1 #187346 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7SA7
- Type
- protein
- Length
- 1,427 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Pockets
- 20 · best druggability 0.70
Structure
x-ray diffraction · 5 distinct chains · 24% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 221 | 21% helix, 28% strand | P43405 |
| B | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 236 | 25% helix, 25% strand | P43405 |
| C | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 218 | 20% helix, 27% strand | P43405 |
| D | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 244 | 23% helix, 25% strand | P43405 |
| E, F | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 254 | 28% helix, 24% strand | P43405 |
Pockets
20 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 567 | 0.70 | 0.79 | 57 | empty |
| 2 | 314 | 0.65 | 0.81 | 49 | empty |
| 3 | 244 | 0.64 | 0.82 | 36 | empty |
| 4 | 446 | 0.64 | 0.77 | 50 | empty |
| 5 | 135 | 0.58 | 0.84 | 25 | empty |
Interfaces
7 interfaces between chains.
- D–F · 465 Ų buried · 1 hydrogen bond · protein-protein
- A–F · 207 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 189 Ų buried · 2 hydrogen bonds · protein-protein
- B–E · 66 Ų buried · 0 hydrogen bonds · protein-protein
- B–C · 65 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7SA7 · Crystal structure of the apo SH2 domains of Syk · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 7SA7 · PDBe 7SA7 · UniProt P43405
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