MolNFT v1 · #187252 · protein

The crystal structure of human ISG15

7S6P · Ubiquitin-like protein ISG15: “The crystal structure of human ISG15”. X-ray diffraction, 9 pockets (best druggability 0.71). MolNFT v1 #187252 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7S6P
Type: protein
Length: 903 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin-like protein ISG15
UniProt: P05161
Pockets: 9 · best druggability 0.71

Structure

x-ray diffraction · 4 distinct chains · 25% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C, E	Ubiquitin-like protein ISG15	protein	151	25% helix, 33% strand	P05161
B	Ubiquitin-like protein ISG15	protein	152	25% helix, 34% strand	P05161
D	Ubiquitin-like protein ISG15	protein	150	25% helix, 32% strand	P05161
F	Ubiquitin-like protein ISG15	protein	148	26% helix, 34% strand	P05161

Pockets

9 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	771	0.71	0.77	76	empty
2	743	0.70	0.77	79	empty
3	678	0.70	0.77	50	empty
4	625	0.69	0.78	53	empty
5	660	0.69	0.77	58	empty

Interfaces

12 interfaces between chains.

A–B · 973 Å² buried · 3 hydrogen bonds · protein-protein
C–D · 964 Å² buried · 5 hydrogen bonds · protein-protein
E–F · 948 Å² buried · 3 hydrogen bonds · protein-protein
B–C · 272 Å² buried · 5 hydrogen bonds · protein-protein
A–D · 260 Å² buried · 4 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 3 disulfide (disulfide).

Compared structures

7S6P · The crystal structure of human ISG15 · the same entry in another collection · chain F against F, TM-score 1.00
P05161 · AlphaFold monomer V2.0 prediction for ubiquitin-like protein ISG15 (P05161) · a predicted model of the same protein · chain A against A, TM-score 0.87

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05161
Elsewhere: RCSB PDB 7S6P · PDBe 7S6P · UniProt P05161

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.