MolNFT v1 · #187117 · protein
Cryo-EM structure of human NKCC1 K289NA492EL671C
7S1Z · Solute carrier family 12 member 2: “Cryo-EM structure of human NKCC1 K289NA492EL671C”. Electron microscopy, 16 pockets (best druggability 0.85). MolNFT v1 #187117 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7S1Z
- Type
- protein
- Length
- 944 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Solute carrier family 12 member 2
- UniProt
- P55011
- Pockets
- 16 · best druggability 0.85
Structure
electron microscopy · 1 distinct chain · 64% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Solute carrier family 12 member 2 | protein | 472 | 64% helix, 0% strand | P55011 |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 838 | 0.85 | 0.86 | 65 | empty |
| 2 | 299 | 0.71 | 0.84 | 31 | empty |
| 3 | 311 | 0.71 | 0.84 | 34 | empty |
| 4 | 310 | 0.60 | 0.78 | 42 | empty |
| 5 | 280 | 0.58 | 0.78 | 38 | empty |
Interfaces
1 interface between chains.
- A–B · 860 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P55011
- Elsewhere: RCSB PDB 7S1Z · PDBe 7S1Z · UniProt P55011
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