MolNFT v1 · #187115 · protein

Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide

7S1X: “Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide”. Electron microscopy, 2 ligands (K, CL). MolNFT v1 #187115 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7S1X
Type: protein
Length: 1,744 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P55011
Ligands: K, CL

Structure

electron microscopy · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
B, A	—	protein	872	—	P55011

Ligands and binding sites

K · Potassium ion · metal · 2 copies · chains B, A
CL · Chloride ion · ion · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7S1X · Cryo-EM structure of human NKCC1 K289NA492EL671C bound with bumetanide · the same entry in another collection · chain B against B, TM-score 1.00
P55011 · AlphaFold monomer V2.0 prediction for solute carrier family 12 member 2 (P55011) · a predicted model of the same protein · chain B against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P55011
Elsewhere: RCSB PDB 7S1X · PDBe 7S1X · UniProt P55011

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