MolNFT v1 · #187108 · protein

Structure of human POT1C

7S1O · Protection of telomeres protein 1: “Structure of human POT1C”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.66). MolNFT v1 #187108 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7S1O
Type: protein
Length: 604 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protection of telomeres protein 1
UniProt: Q9NUX5
Ligands: ZN
Pockets: 6 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Protection of telomeres protein 1	protein	302	21% helix, 33% strand	Q9NUX5

Ligands and binding sites

ZN · Zinc ion · metal · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	556	0.66	0.77	65	empty
2	118	0.65	0.88	29	empty
3	137	0.52	0.80	26	empty
4	52	0.29	0.75	18	empty
5	59	0.29	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 606 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

7S1O · Structure of human POT1C · the same entry in another collection · chain A against A, TM-score 1.00
Q9NUX5 · AlphaFold monomer V2.0 prediction for protection of telomeres protein 1 (Q9NUX5) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NUX5
Elsewhere: RCSB PDB 7S1O · PDBe 7S1O · UniProt Q9NUX5

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