MolNFT v1 · #187101 · protein

Crystal structure of alpha-cop-WD40 domain R57A mutant

7S16 · Coatomer subunit alpha: “Crystal structure of alpha-cop-WD40 domain R57A mutant”. X-ray diffraction, 2 ligands (ACE, NA), 1 pocket (best druggability 0.82). MolNFT v1 #187101 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7S16
Type: protein
Length: 321 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Coatomer subunit alpha
UniProt: Q96WV5
Ligands: ACE, NA
Pockets: 1 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 2% helix, 53% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Coatomer subunit alpha	protein	321	2% helix, 53% strand	Q96WV5

Ligands and binding sites

ACE · Acetyl group · ligand · chains A
NA · Sodium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	755	0.82	0.85	54	NA

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

7S16 · Crystal structure of alpha-COP-WD40 domain R57A mutant · the same entry in another collection · chain A against A, TM-score 1.00
Q96WV5 · AlphaFold monomer V2.0 prediction for putative coatomer subunit alpha (Q96WV5) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96WV5
Elsewhere: RCSB PDB 7S16 · PDBe 7S16 · UniProt Q96WV5

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