MolNFT v1 · #187036 · protein
Structure of the complex of lbd-tmd part of AMPA receptor GLUA2 with auxiliary subunit GSG1L bound to agonist quisqualate
7RYZ · Glutamate receptor 2: “Structure of the complex of lbd-tmd part of AMPA receptor GLUA2 with auxiliary subunit GSG1L bound to agonist…”. Electron microscopy, 1 ligand (QUS), 20 pockets (best druggability 0.82). MolNFT v1 #187036 on…
- PDB
- 7RYZ
- Type
- protein
- Length
- 2,014 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2
- UniProt
- P19491
- Ligands
- QUS
- Pockets
- 20 · best druggability 0.82
Structure
electron microscopy · 2 distinct chains · 50% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Glutamate receptor 2 | protein | 597 | 52% helix, 13% strand | P19491 |
| B, D | Glutamate receptor 2 | protein | 410 | 47% helix, 13% strand | P19491 |
Ligands and binding sites
- QUS · (S)-2-amino-3-(3,5-dioxo-[1,2,4]oxadiazolidin-2-yl)-propionic acid · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 785 | 0.82 | 0.85 | 85 | empty |
| 2 | 708 | 0.82 | 0.85 | 67 | empty |
| 3 | 161 | 0.81 | 0.96 | 21 | empty |
| 4 | 76 | 0.73 | 0.97 | 19 | QUS |
| 5 | 163 | 0.73 | 0.91 | 36 | empty |
Interfaces
5 interfaces between chains.
- C–D · 2853 Ų buried · 14 hydrogen bonds · protein-protein
- A–B · 2751 Ų buried · 7 hydrogen bonds · protein-protein
- B–C · 2719 Ų buried · 15 hydrogen bonds · protein-protein
- A–D · 2695 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 62 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7RYZ · Structure of the complex of LBD-TMD part of AMPA receptor GluA2 with auxiliary subunit… · the same entry in another collection · chain D against D, TM-score 1.00
- P19491 · AlphaFold monomer V2.0 prediction for glutamate receptor 2 (P19491) · a predicted model of the same protein · chain D against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 7RYZ · PDBe 7RYZ · UniProt P19491
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.