MolNFT v1 · #186988 · protein
Crystal structure of the tir domain from the grapevine disease resistance protein RUN1
7RX1: “Crystal structure of the tir domain from the grapevine disease resistance protein RUN1”. X-ray diffraction, 1 ligand (SO4), 1 pocket (best druggability 0.72). MolNFT v1 #186988 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7RX1
- Type
- protein
- Length
- 345 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Disease resistance protein RUN1
- EC
- 3.2.2.6, 3.2.2.-
- UniProt
- V9M398
- Ligands
- SO4
- Pockets
- 1 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Disease resistance protein RUN1 (EC 3.2.2.6, 3.2.2.-) | protein | 174 | 53% helix, 14% strand | V9M398 |
| B | Disease resistance protein RUN1 (EC 3.2.2.6, 3.2.2.-) | protein | 171 | 51% helix, 15% strand | V9M398 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 7 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 488 | 0.72 | 0.81 | 54 | SO4 |
Interfaces
1 interface between chains.
- A–B · 331 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 7RX1 · Crystal structure of the TIR domain from the grapevine disease resistance protein RUN1 · the same entry in another collection · chain A against A, TM-score 1.00
- V9M398 · AlphaFold monomer V2.0 prediction for disease resistance protein RUN1 (V9M398) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt V9M398
- Elsewhere: RCSB PDB 7RX1 · PDBe 7RX1 · UniProt V9M398
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