MolNFT v1 · #186970 · protein

Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric inhibitor agi-41998

7RWH: “Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM and allosteric…”. X-ray diffraction, 3 ligands (7UI, MG, CL). MolNFT v1 #186970 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7RWH
Type: protein
Length: 386 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P31153
Ligands: 7UI, MG, CL

Structure

x-ray diffraction · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	386	—	P31153

Ligands and binding sites

7UI · 8-(4-bromophenyl)-6-(4-methoxyphenyl)-2-[2,2,2-tris(fluoranyl)ethylamino]pyrido[4,3-d]pyrimidin-7-ol · ligand · chains A
MG · Magnesium ion · metal · 3 copies · chains A
CL · Chloride ion · ion · chains A
EDO · 1,2-ethanediol · additive · 4 copies · chains A
GOL · Glycerol · additive · chains A
1PE · Pentaethylene glycol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7RWH · Crystal structure of human methionine adenosyltransferase 2A (MAT2A) in complex with SAM… · the same entry in another collection · chain A against A, TM-score 1.00
P31153 · AlphaFold monomer V2.0 prediction for S-adenosylmethionine synthase isoform type-2… · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P31153
Elsewhere: RCSB PDB 7RWH · PDBe 7RWH · UniProt P31153

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.